Go Back
–+ servings

Spicy Southern Chicken Spaghetti Casserole

The ultimate comfort food that brings a little heat, a lot of flavor, and a touch of Southern charm to your dinner table. This casserole combines tender pasta, creamy cheese, and spicy chicken into one baked masterpiece.
Print Recipe Pin Recipe
Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Servings: 6 servings
Course: Dinner, Main Course
Cuisine: Comfort Food, Southern
Calories: 450
Ingredients Method Nutrition Notes

Ingredients
  

Main Ingredients
  • 2 cups cooked chicken (shredded) Use leftover roasted chicken or rotisserie chicken
  • 12 oz spaghetti pasta Cooked al dente
  • 1 can cream of chicken soup Adds creamy texture
  • 1 can diced tomatoes with green chilies Adds tang and spice
  • 1 cup bell peppers (red & green), diced For color and flavor
  • 1 small onion, finely chopped
  • 2 cloves garlic, minced
  • 2 cups cheddar cheese, shredded, divided
  • 4 oz cream cheese, softened For creaminess
  • 1 cup chicken broth Helps blend the sauce
  • 1 tbsp Cajun seasoning Adds Southern spice
  • 1 tbsp olive oil For sautéing
  • salt & pepper To taste

Method
 

Preparation
  1. Preheat and prepare: Set your oven to 350°F (175°C). Lightly grease a large baking dish with butter or nonstick spray.
  2. Cook the spaghetti: Boil pasta until al dente, then drain and set aside. Don’t overcook—it will bake later.
  3. Sauté the vegetables: In a large skillet, heat olive oil and sauté onion, garlic, and bell peppers until soft and fragrant.
  4. Mix the sauce: Add the cream of chicken soup, diced tomatoes with chilies, cream cheese, and half of the shredded cheddar to the skillet. Stir until creamy and smooth.
  5. Add chicken and spices: Stir in shredded chicken, Cajun seasoning, salt, and pepper. Pour in chicken broth to loosen the sauce.
  6. Combine with pasta: Toss in the cooked spaghetti and coat evenly with the creamy, spicy mixture.
  7. Bake to perfection: Transfer everything into the prepared dish, top with the remaining cheese, and bake for 25–30 minutes until bubbly and golden.

Nutrition

Serving: 1gCalories: 450kcalCarbohydrates: 50gProtein: 32gFat: 20gSaturated Fat: 10gSodium: 900mgFiber: 2gSugar: 4g

Notes

This Spicy Southern Chicken Spaghetti Casserole is a versatile dish that can be customized to suit your taste with various heat levels and additional ingredients. It’s also freezer-friendly, making it great for meal prep.

Tried this recipe?

Let us know how it was!